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SiFi-CC: ON-LINE MONITORING OF DOSE DISTRIBUTION IN PROTON THERAPY USING HEAVY SCINTILLATING FIBERS

Context

The project SiFi-CC is a joint effort of a group of researchers and students from the Jagiellonian University in Kraków, Poland and RWTH Aachen University, Germany. The aim of the project is the development of a method for on-line monitoring of a cancer treatment called proton therapy. In this kind of treatment, a tumour is irradiated with a proton beam with parameters adjusted such, that protons deposit maximum of their energy in the tumour region, leading to the destruction of tumour cells. For this purpose, a treatment plan is prepared individually for each patient, usually based on CT (computed tomography) or PET (positron emission tomography) images. However, human body undergoes changes, which may lead to misplacement of the applied dose compared to the original plan. Therefore methods for on-line monitoring in proton therapy are sought for, as they would allow preparing better treatment plans for patients, leading to better and safer treatment.

Project

SS 20181109 CrossedFibres.png In our project, we want to test a possible option of design of a setup for proton therapy monitoring. Its operation consists in the detection of gamma radiation, which is produced in a patient's body irradiated with a proton beam. By reconstructing the source of this radiation we can conclude about the location and shape of the deposited dose. We will detect prompt-gamma radiation using long but thin pieces (so-called fibres) of a scintillating material, i.e. the one which shines the light when being traversed by a particle or a gamma ray. This light can be registered with special sensors called silicon photomultipliers. So the name of our project comes from SiPMs and scintillating Fiber-based Compton Camera (SiFi-CC).

The setup we propose has two modes of operation: a Compton camera and a coded-mask, which allow mapping the deposited dose distribution in three or two dimensions, respectively. The two options share a vast part of the hardware, therefore we want to develop them in parallel. First, we will conduct a series of virtual experiments (computer simulations) to find the best possible design option, then we will make sure in the laboratory tests that the simulation results correspond to reality. Once the design is fixed, we will build and test the setup, first in a laboratory, and then in a therapeutic centre with phantoms simulating the human body.

SUPPORTED BY

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RH 20210210 DAADLogo.png

Job offers

OW 20191218 Puzzle ad2020 EN.jpg Such a venture comprises very different tasks: from laboratory tests, through computer simulations, building a modern data acquisition system, processing of experimental data and implementation of algorithms for image reconstruction, up to experiments with a proton beam in a therapeutic centre.

If you are interested in joining our group, contact us and ask for our offer for students, PhD students and post-docs.

The project is financed by the National Science Centre, Poland, within the SONATA BIS 7 program, foreseen to be completed in September 2023.

Collaboration

The project SiFi-CC is a joint effort of the group:

OW2019 square.png SS 20181110 r.hetzel.png KR 20190827 lalik.jpeg SS 20181110 a.magiera.png RH 20200302 a.stahl.jpg NN 20201124 Rafecas.JPG MW 20210203 random.jpg
Aleksandra Wrońska1 Ronja Hetzel2 Rafał Lalik1 Andrzej Magiera1 Achim Stahl2 Magdalena Rafecas5 Mark Wong1
post-doc, PI post-doc post-doc professor professor professor post-doc
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Jonas Kasper2 Majid Kazemi-Kozuni1 Katarzyna Rusiecka1 Vitalii Urbanevych1 Nadja Kohlhase5 Magdalena Kołodziej1 Awal Awal2 Barbara Kołodziej1 Anna Władyszewska1 Monika Łukowicz1
PhD student PhD student PhD student PhD student PhD student PhD student student student student student


Former members, also those working on the gCCB project:

Piotr Bednarczyk3, Anna Bekas1, Daniel Böckenhoff2, Arshiya Anees Ahmed1, Arkadiusz Bubak4, Richard Chomjak1, Sabine Feyen2, Grzegorz Gazdowicz1, Aleksandra Kaszlikowska1 Laurent Kelleter2, Adam Konefał4, Wojciech Kozyra1, Karim Laihem2, Johannes Leidner2, Grzegorz Obrzud1, Marek Pałka1, Damian Stachura1, Szymon Świstun1, Aneta Wiśniewska1, Mirosław Ziębliński3

1Institute of Physics, Jagiellonian University, Kraków 2RWTH University, Aachen 3Institute of Nuclear Physics PAN, Kraków 4University of Silesia, Katowice 5Institute of Medical Engineering, University of Lübeck


Publications

2021

K. Rusiecka, R. Hetzel, J. Kasper, M. Kazemi Kozani, N. Kohlhase, M. Kołodziej R. Lalik, A. Magiera, W. Migdał, M. Rafecas, A. Stahl, V. Urbanevych, M. L. Wong, A. Wrońska
A systematic study of LYSO:Ce, LuAG:Ce and GAGG:Ce scintillating fibers properties
Journal of Instrumentation 16 (2021) P11006, doi: 10.1088/1748-0221/16/11/P11006

A. Wrońska, J. Kasper, A. A. Ahmed, A. Andres, P. Bednarczyk, G. Gazdowicz, K. Herweg, R. Hetzel, A. Konefał, P. Kulessa, A. Magiera, K. Rusiecka, D. Stachura, A. Stahl, M. Ziębliński
Prompt-gamma emission in GEANT4 revisited and confronted with experiment
Physica Medica 88 (2021) 250-261, doi: 10.1016/j.ejmp.2021.07.018, pdf

M. Kazemi Kozani and A. Magiera on behalf of the SiFi-CC group
Machine Learning-based Event Recognition in Compton Camera Imaging for Proton Therapy Monitoring
IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE, pdf, poster, presentation

A. Wrońska, D. Dauvergne
Range verification by means of prompt-gamma detection in particle therapy
chapter in the book Radiation Detection Systems, CRC Press/Routledge, www preprint in HAL

2020

A. Wrońska for the SiFi-CC collaboration
White Book, report on status of research and infrastructure of nuclear physics in Poland, prepared as the proceedings of the conference Przyszłość fizyki jądrowej niskich energii w Polsce a rozwój krajowej infrastruktury badawczej, held in Warsaw in Jan 2019
White Book, ISBN: 978-83-959188-0-3, published Oct 2020

J. Kasper, K. Rusiecka, R. Hetzel, M. Kazemi Kozani, R. Lalik, A. Magiera, A. Stahl, A. Wrońska
The SiFi-CC project – Feasibility study of a scintillation-fiber-based Compton camera for proton therapy monitoring
Physica Medica 76 (2020) 317-325, doi:10.1016/j.ejmp.2020.07.013, pdf

A. Wrońska for the SiFi-CC group
Prompt gamma imaging in proton therapy - status, challenges and developments
Journal of Physics: Conference Series 1561 (2020) 012021, doi:10.1088/1742-6596/1561/1/012021 pdf

A. Wrońska, R. Hetzel, J. Kasper, R. Lalik, A. Magiera, K. Rusiecka, A. Stahl
Characterisation of components of a scintillation-fiber-based Compton camera
contribution to proceedings of 3rd Jagiellonian Symposium.... in Kraków,
Acta Physica Polonica B, vol. 51 no. 1 (2020) p. 17-25. DOI:10.5506/APhysPolB.51.17

2019

Arshiya A. Ahmed, A. Wrońska, A. Magiera, M. Bartyzel, J.W. Mietelski, R. Misiak, B. Wąs
Reexamination of proton-induced reactions on natMo at 19–26 MeV and study of target yield of resultant radionuclides
Acta Physica Polonica B, vol. 50 (2019) p. 1583, DOI:10.5506/APhysPolB.50.1583

K. Rusiecka et al.
Investigation of the Properties of the Heavy Scintillating Fibers for Their Potential Use in Hadron Therapy Monitoring
chapter in Engineering of Scintillation Materials and Radiation Technologies - Selected Articles of ISMART2018, ISBN 978-3-030-21970-3, Springer Proceedings in Physics 227, pp 195-210
DOI: 10.1007/978-3-030-21970-3_14

A. Wrońska, A. Ruciński
Wyzwania w terapii protonowej – jak leczyć nowotwory lepiej?
Nowoczesne technologie XXI w. – przegląd, trendy i badania. Tom 1, Wydawnictwo Naukowe TYGIEL sp. z o.o., 2019, ISBN: 978-83-65932-70-9, pdf

2018

K. Rusiecka et al.
Shape of the spectral line and gamma angular distribution of the 12C(p,p'gamma4.44)12C reaction
Acta Physica Polonica B 49 (2018) 1637-1652 full text

2017

A. Wrońska et al., Experimental verification of key cross sections for prompt-gamma imaging in proton therapy
Presented at the 2nd Jagiellonian Symposium on Fundamental and Applied Subatomic Physics, Kraków, Poland, June 3–11, 2017
Acta Phys. Pol.B 48 (2017) 1631.
DOI:10.5506/APhysPolB.48.1631

A.Chrobak et al., Comparison of various models of Monte Carlo GEANT 4 code in simulations of prompt gamma production
Zakopane Conference on Nuclear Physics Extremes of the Nuclear Landscape
Acta Phys. Pol.B 48 (2017) 675. full text

L. Kelleter et al. Spectroscopic study of prompt-gamma emission for range verification in proton therapy
Physica Medica 34 (2017) 7-17
DOI:10.1016/j.ejmp.2017.01.003
Submitted version: pdf

2016

A. Wrońska, Gamma Emission in Hadron Therapy - Towards New Tols of Quality Assurance
contribution to conference proceedings pdf
Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2015 IEEE, 2016, DOI:10.1109/NSSMIC.2015.7582186

K. Rusiecka et al., Determination of Gamma Angular Distribution from the Shape of Spectral Line for the First Excited State of Carbon Nucleus
World Journal of Nuclear Science and Technology 6 (2016) 63-70. full text

2015

A. Wrońska et al., Gamma Emission in Hadron Therapy — Experimental Approach
Contribution to the Proceedings of Zakopane Conference on Nuclear Physics Extremes of the Nuclear Landscape
Acta Phys. Pol. B 46 (2015) 753. full text